- Lutetium Please visit the Lutetium element page for information specific to the chemical element of the periodic table.
- Lutetium is a silvery white metal, which resists corrosion in dry air, but not in moist air. Lutetium is the last element in the lanthanide series, and it is traditionally counted among the rare earths.
Lutetium and its compounds have found some applications, the most important of these is the use of the oxide in making catalysts for cracking hydrocarbons in the petrochemical industry. But there are other more specialist uses, such as using the radioactive Lutetium-177 isotope in cancer therapy.
Generic Name: lutetium Lu 177 dotatate (loo TEE shee um LOO 177 DOE ta tate)
Dosage Forms: intravenous solution (370 MBq/mL)
What is lutetium Lu 177 dotatate?
Lutetium Lu 177 dotatate is a radioactive medicine that binds itself to a specific part of certain tumor cells, allowing the radiation to enter and destroy those cells.
Lutetium Lu 177 dotatate is used to treat certain cancers of the digestive tract, including the stomach, pancreas, and intestines.
Lutetium Lu 177 dotatate may also be used for purposes not listed in this medication guide.
Do not become pregnant or breast-feed a baby while receiving lutetium Lu 177 dotatate.
Both men and women using lutetium Lu 177 dotatate should use effective birth control to prevent pregnancy. Lutetium Lu 177 dotatate can harm an unborn baby or cause birth defects if the mother or father is using this medicine.
Before taking this medicine
You should not use lutetium Lu 177 dotatate if you are pregnant or breast-feeding.
Lutetium Lu 177 dotatate can harm an unborn baby or cause birth defects if the mother or the father is receiving this medicine.
If you are a woman, use effective birth control to prevent pregnancy while you are receiving this medicine and for at least 7 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is receiving lutetium Lu 177 dotatate.
Do not breast-feed while receiving lutetium Lu 177 dotatate, and for at least 4 months after your last dose.
Tell your doctor if you have ever had:
high blood pressure; or
any type of radiation treatment.
Lutetium Lu 177 dotatate may cause other types of cancer, such as leukemia. Ask your doctor about this risk.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because lutetium Lu 177 dotatate may harm the baby if a pregnancy does occur.
How is lutetium Lu 177 dotatate given?
Lutetium Lu 177 dotatate is given as an infusion into a vein. A healthcare provider will give you this injection once every 8 weeks for a total of 4 doses.
lutetium Lu 177 dotatate must be given slowly, and the infusion can take 30 to 40 minutes to complete.
After each infusion, you will be given another medicine called octreotide, which is injected into a muscle. Octreotide injections are usually given once every 4 weeks for up to 18 months.
You may be given other medications to help prevent serious side effects or allergic reaction. Keep using these medicines for as long as your doctor has prescribed.
Drink plenty of fluids while being treated with this medicine. You should urinate often, to help keep your kidneys working properly.
You will need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.
For up to 30 days after you are treated with lutetium Lu 177 dotatate, your urine will contain radiation. To prevent the spread of this radiation, use a toilet rather than a urinal, and sit on the toilet while urinating.
Always wash your hands after using the bathroom. Avoid handling any clean-up of your stools or urine without wearing latex rubber gloves. If another person is handling your urine, they should wear gloves, eye protection, and a mask to cover the nose and mouth.
When cleaning any spills of bodily fluid, use only disposable cleaning cloths that can be flushed down a toilet. Ask your doctor or health department how to dispose of any bodily fluid spills that cannot be flushed down a toilet.
Wash any soiled clothing separately from the laundry of other people in your home.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your lutetium Lu 177 dotatate injection.
What happens if I overdose?
Since lutetium Lu 177 dotatate is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving lutetium Lu 177 dotatate?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Lutetium Lu 177 dotatate side effects
Get emergency medical help if you have signs of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
little or no urination;
flushing (warmth, redness, or tingly feeling);
a light-headed feeling, like you might pass out;
wheezing, chest tightness, trouble breathing;
low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or
low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling. Melodyne editor vst download.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
high blood sugar;
low potassium; or
abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Lutetium Uses In Everyday Life
Lutetium Lu 177 dotatate dosing information
Usual Adult Dose for Neuroendocrine Carcinoma:
Intravenous infusion: 7.4 GBq (200 mCi) every 8 weeks for a total of 4 doses.
Premedication and Concomitant Medications:
-Discontinue long-acting somatostatin analogs (e.g., long-acting octreotide) for at least 4 weeks prior to initiating this drug. Administer short-acting octreotide as needed; discontinue at least 24 hours prior to initiating this drug.
-During treatment: Administer long-acting octreotide 30 mg intramuscularly 4 to 24 hours after each dose of this drug. Do not administer long-acting octreotide within 4 weeks of each subsequent dose. Short-acting octreotide may be given for symptomatic management during treatment with this drug, but must be withheld for at least 24 hours before each dose of this drug.
-Following treatment: Continue long-acting octreotide 30 mg intramuscularly every 4 weeks after completing this drug until disease progression or for up to 18 months following treatment initiation.
-Administer antiemetics 30 minutes before the recommended amino acid solution.
Amino Acid Solution:
-Initiate an intravenous amino acid solution containing L-lysine and L-arginine 30 minutes before administering this drug.
-Use a three-way valve to administer amino acids using the same venous access as this drug or administer amino acids through a separate venous access in the patient's other arm.
-Continue the infusion during, and for at least 3 hours after infusion of this drug.
-Do not decrease the dose of the amino acid solution if the dose of this drug is reduced.
-Dose modifications due to adverse reactions are provided in the dose adjustment section.
-Radiation Dosimetry: The maximum penetration in tissue is 2.2 mm and the mean penetration is 0.67 mm.
Use: Treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut, midgut, and hindgut neuroendocrine tumors in adults.
What other drugs will affect lutetium Lu 177 dotatate?
Other drugs may affect lutetium Lu 177 dotatate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
More about lutetium lu 177 dotatate
- During Pregnancy or Breastfeeding
- Other brands
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2021 Cerner Multum, Inc. Version: 1.01.
The Element Lutetium
[Click for Isotope Data]
Atomic Number: 71
Atomic Weight: 174.9668
Melting Point: 1936 K (1663°C or 3025°F)
Boiling Point: 3675 K (3402°C or 6156°F)
Density: 9.84 grams per cubic centimeter
Phase at Room Temperature: Solid
Element Classification: Metal
Period Number: 6
Group Number: 3
Group Name: Lanthanide
What's in a name? From an ancient name for the city of Paris, Lutetia.
Say what? Lutetium is pronounced as loo-TEE-shee-em.
History and Uses:
The mineral gadolinite ((Ce, La, Nd, Y)2FeBe2Si2O10), discovered in a quarry near the town of Ytterby, Sweden, has been the source of a great number of rare earth elements. In 1843, Carl Gustaf Mosander, a Swedish chemist, was able to separate gadolinite into three materials, which he named yttria, erbia and terbia. As might be expected considering the similarities between their names and properties, scientists soon confused erbia and terbia and, by 1877, had reversed their names. What Mosander called erbia is now called terbia and visa versa. In 1878 Jean Charles Galissard de Marignac, a Swiss chemist, discovered that erbia was itself composed of two components. One component was named ytterbia by Marignac while the other component retained the name erbia.
Marignac believed that ytterbia was a compound of a new element, which he named ytterbium. Other chemists produced and experimented with ytterbium in an attempt to determine some of it's properties. Unfortunately, different scientists obtained different results from the same experiments. While some scientists believed that these inconsistent results were caused by poor procedures or faulty equipment, Georges Urbain, a French chemist, believed that ytterbium wasn't an element at all, but a mixture of two elements. In 1907, Urbain was able to separate ytterbium into two elements. Urbain named one of the elements neoytterbium (new ytterbium) and the other element lutecium. Carl Auer von Welsbach, an Austrian chemist working independently of Urbain, reached the same conclusions at nearly the same time. Welsbach chose the names albebaranium and cassiopium for these elements. Urbain was eventually credited with the discovery of the elements and won the right to name them, although chemists later changed the name neoytterbium back to ytterbium and changed the spelling of lutecium to lutetium. Today, lutetium is primarily obtained through an ion exchange process from monazite sand ((Ce, La, Th, Nd, Y)PO4), a material rich in rare earth elements.
Lutetium is one of the most difficult elements to prepare and has no large scale practical uses, although some of its radioactive isotopes can be used as a catalyst in the cracking of petroleum products and a catalyst in some hydrogenation and polymerization processes.
Estimated Crustal Abundance: 8×10-1 milligrams per kilogram
Estimated Oceanic Abundance: 1.5×10-7 milligrams per liter
Number of Stable Isotopes: 1 (View all isotope data)
Ionization Energy: 5.426 eV
Oxidation States: +3
Electron Shell Configuration:
3s2 3p6 3d10
4s2 4p6 4d10 4f14
5s2 5p6 5d1
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